Welcome to epiCS

The use of reconstructed human skin models has evolved tremendously in the past years. The similarity to human skin as well as the availability from commercial sources helped to establish these tissues as valuable tools for different applications.

Commercially available skin models can be divided into two groups:

1. Reconstructed human full thickness skin models.
2. Reconstructed human epidermis models.

Reconstructed human full thickness skin models are composed of a dermal compartment containing human skin fibroblasts embedded in a collagen matrix and human keratinocytes seeded on top to form the epidermis. Reconstructed human epidermis models are composed of human keratinocytes seeded on a polycarbonate membrane to form the epidermis.

There are also a lot of different skin models established in the academia world with a variety of different cell types and applications.

We are focusing on reconstructed human epidermis (RhE) models that are widely used for in vitro toxicology, efficacy testing and basic research. Contract research organisations (CRO), chemicals, cosmetics, pharmaceuticals and biotech industries as well as basic research laboratories carry out a number of different studies for different applications.

This web-site describes the use of reconstructed human epidermis models for most of the applications to help you to decide which model suits your needs best.

It describes the background for both toxicity testing and research use, providing information such as protocols, guidelines and more.

The information provided here will not answer all of your questions but gives you a first introduction. For further in depth, scientific and technical information, please contact CellSystems by e-mail or telephone.